PhD students and postdocs

We are looking for new PhD students and postdocs.

Our Lab is interested in the host defense cell signaling pathways.  Current research focus is elucidation of the molecular mechanism by which host cells switch signaling pathways between inflammation and cell death. Specifically, we are investigating our long-time molecule of interest, mitogen-activated protein kinase kinase kinase 7 (MAP3K7), known as TAK1 (recent publications, see below). 

PI is a study section member of NIH and has extensive experiences in supporting career development.  As the lab is small, the successful candidate will play a major role in the NIH funded project, and will receive in-person trainings toward an independent researcher.  

Recent Publications:

1. Sai, K., Nakanishi, A., Scofield, K.M., Tokarz, D.A., Linder, K.E., Cohen, T.J., and Ninomiya-Tsuji, J. (2023). Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer’s disease mouse models. J Cell Sci 136 doi: 10.1242/jcs.260102.

2. Lopez-Perez, W., Sai, K., Sakamachi, Y., Parsons, C., Kathariou, S., and Ninomiya-Tsuji, J. (2021). TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization. Proc Natl Acad Sci U S A 118.

3. Sai, K., Parsons, C., House, J.S., Kathariou, S., and Ninomiya-Tsuji, J. (2019). Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing. J Cell Biol 218, 1994-2005.

Please contact Ninomiya-Tsuji (jtsuji@ncsu.edu) with CV.